Proteomic profiling of cancer of the gingivo‐buccal complex: Identification of new differentially expressed markers
Identifieur interne : 001F66 ( Main/Exploration ); précédent : 001F65; suivant : 001F67Proteomic profiling of cancer of the gingivo‐buccal complex: Identification of new differentially expressed markers
Auteurs : Rukmini B. Govekar [Inde] ; Anil K. D'Cruz [Inde] ; K. Alok Pathak [Inde, Canada] ; Jaiprakash Agarwal [Inde] ; Ketayun A. Dinshaw [Inde] ; Roshan F. Chinoy [Inde] ; Nikhil Gadewal [Inde] ; Sadhana Kannan [Inde] ; Ravi Sirdeshmukh [Inde] ; Curam S. Sundaram [Inde] ; Siddhi A. Malgundkar [Inde] ; Shubhada V. Kane [Inde] ; Surekha M. Zingde [Inde]Source :
- PROTEOMICS – Clinical Applications [ 1862-8346 ] ; 2009-12.
English descriptors
- KwdEn :
Abstract
Tobacco‐related oral cancer is the most common cancer among Indian males, gingivo‐buccal complex (GBC) being the most affected subsite due to the habit of chewing tobacco. Proteins from the lysates of microdissected normal and transformed epithelium from clinically well‐characterized tissue samples of the GBC were separated by two‐dimensional gel electrophoresis to identify differentially expressed proteins. Eleven protein spots showed differential expression, which could withstand the stringency of statistical evaluation. The observations were confirmed with additional tissues. Nine of these differentiators were identified by MS as lactate dehydrogenase B, α‐enolase, prohibitin, cathepsin D, apolipoprotein A‐I, tumor protein translationally controlled‐1, an SFN family protein, 14‐3‐3σ and tropomyosin. Cluster analysis indicated that these proteins, as a coexpressed set, could distinguish normal and transformed epithelium. Functionally, these differentiator molecules are relevant to the pathways and processes that have been previously implicated in oral carcinogenesis and could therefore be investigated further as a panel of markers for management of cancer of the GBC.
Url:
DOI: 10.1002/prca.200900023
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002780
- to stream Istex, to step Curation: 002780
- to stream Istex, to step Checkpoint: 000742
- to stream Main, to step Merge: 002119
- to stream Main, to step Curation: 001F66
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proteomic profiling of cancer of the gingivo‐buccal complex: Identification of new differentially expressed markers</title><author><name sortKey="Govekar, Rukmini B" sort="Govekar, Rukmini B" uniqKey="Govekar R" first="Rukmini B." last="Govekar">Rukmini B. Govekar</name></author><author><name sortKey="D Cruz, Anil K" sort="D Cruz, Anil K" uniqKey="D Cruz A" first="Anil K." last="D'Cruz">Anil K. D'Cruz</name></author><author><name sortKey="Alok Pathak, K" sort="Alok Pathak, K" uniqKey="Alok Pathak K" first="K." last="Alok Pathak">K. Alok Pathak</name></author><author><name sortKey="Agarwal, Jaiprakash" sort="Agarwal, Jaiprakash" uniqKey="Agarwal J" first="Jaiprakash" last="Agarwal">Jaiprakash Agarwal</name></author><author><name sortKey="Dinshaw, Ketayun A" sort="Dinshaw, Ketayun A" uniqKey="Dinshaw K" first="Ketayun A." last="Dinshaw">Ketayun A. Dinshaw</name></author><author><name sortKey="Chinoy, Roshan F" sort="Chinoy, Roshan F" uniqKey="Chinoy R" first="Roshan F." last="Chinoy">Roshan F. Chinoy</name></author><author><name sortKey="Gadewal, Nikhil" sort="Gadewal, Nikhil" uniqKey="Gadewal N" first="Nikhil" last="Gadewal">Nikhil Gadewal</name></author><author><name sortKey="Kannan, Sadhana" sort="Kannan, Sadhana" uniqKey="Kannan S" first="Sadhana" last="Kannan">Sadhana Kannan</name></author><author><name sortKey="Sirdeshmukh, Ravi" sort="Sirdeshmukh, Ravi" uniqKey="Sirdeshmukh R" first="Ravi" last="Sirdeshmukh">Ravi Sirdeshmukh</name></author><author><name sortKey="Sundaram, Curam S" sort="Sundaram, Curam S" uniqKey="Sundaram C" first="Curam S." last="Sundaram">Curam S. Sundaram</name></author><author><name sortKey="Malgundkar, Siddhi A" sort="Malgundkar, Siddhi A" uniqKey="Malgundkar S" first="Siddhi A." last="Malgundkar">Siddhi A. Malgundkar</name></author><author><name sortKey="Kane, Shubhada V" sort="Kane, Shubhada V" uniqKey="Kane S" first="Shubhada V." last="Kane">Shubhada V. Kane</name></author><author><name sortKey="Zingde, Surekha M" sort="Zingde, Surekha M" uniqKey="Zingde S" first="Surekha M." last="Zingde">Surekha M. Zingde</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B954DF32520FA520104A6CE0C8025775F5774D2C</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/prca.200900023</idno><idno type="url">https://api-v5.istex.fr/document/B954DF32520FA520104A6CE0C8025775F5774D2C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002780</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002780</idno><idno type="wicri:Area/Istex/Curation">002780</idno><idno type="wicri:Area/Istex/Checkpoint">000742</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000742</idno><idno type="wicri:doubleKey">1862-8346:2009:Govekar R:proteomic:profiling:of</idno><idno type="wicri:Area/Main/Merge">002119</idno><idno type="wicri:Area/Main/Curation">001F66</idno><idno type="wicri:Area/Main/Exploration">001F66</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Proteomic profiling of cancer of the gingivo‐buccal complex: Identification of new differentially expressed markers</title><author><name sortKey="Govekar, Rukmini B" sort="Govekar, Rukmini B" uniqKey="Govekar R" first="Rukmini B." last="Govekar">Rukmini B. Govekar</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai</wicri:regionArea><wicri:noRegion>Navi Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="D Cruz, Anil K" sort="D Cruz, Anil K" uniqKey="D Cruz A" first="Anil K." last="D'Cruz">Anil K. D'Cruz</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Hospital, Parel, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Alok Pathak, K" sort="Alok Pathak, K" uniqKey="Alok Pathak K" first="K." last="Alok Pathak">K. Alok Pathak</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Hospital, Parel, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Current Address: University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Agarwal, Jaiprakash" sort="Agarwal, Jaiprakash" uniqKey="Agarwal J" first="Jaiprakash" last="Agarwal">Jaiprakash Agarwal</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Hospital, Parel, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Dinshaw, Ketayun A" sort="Dinshaw, Ketayun A" uniqKey="Dinshaw K" first="Ketayun A." last="Dinshaw">Ketayun A. Dinshaw</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Hospital, Parel, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Chinoy, Roshan F" sort="Chinoy, Roshan F" uniqKey="Chinoy R" first="Roshan F." last="Chinoy">Roshan F. Chinoy</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Hospital, Parel, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Gadewal, Nikhil" sort="Gadewal, Nikhil" uniqKey="Gadewal N" first="Nikhil" last="Gadewal">Nikhil Gadewal</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai</wicri:regionArea><wicri:noRegion>Navi Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Kannan, Sadhana" sort="Kannan, Sadhana" uniqKey="Kannan S" first="Sadhana" last="Kannan">Sadhana Kannan</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai</wicri:regionArea><wicri:noRegion>Navi Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Sirdeshmukh, Ravi" sort="Sirdeshmukh, Ravi" uniqKey="Sirdeshmukh R" first="Ravi" last="Sirdeshmukh">Ravi Sirdeshmukh</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Cellular and Molecular Biology, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Sundaram, Curam S" sort="Sundaram, Curam S" uniqKey="Sundaram C" first="Curam S." last="Sundaram">Curam S. Sundaram</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Cellular and Molecular Biology, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Malgundkar, Siddhi A" sort="Malgundkar, Siddhi A" uniqKey="Malgundkar S" first="Siddhi A." last="Malgundkar">Siddhi A. Malgundkar</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai</wicri:regionArea><wicri:noRegion>Navi Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Kane, Shubhada V" sort="Kane, Shubhada V" uniqKey="Kane S" first="Shubhada V." last="Kane">Shubhada V. Kane</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Hospital, Parel, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Zingde, Surekha M" sort="Zingde, Surekha M" uniqKey="Zingde S" first="Surekha M." last="Zingde">Surekha M. Zingde</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai</wicri:regionArea><wicri:noRegion>Navi Mumbai</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">PROTEOMICS – Clinical Applications</title><title level="j" type="abbrev">Prot. Clin. Appl.</title><idno type="ISSN">1862-8346</idno><idno type="eISSN">1862-8354</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2009-12">2009-12</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1451">1451</biblScope><biblScope unit="page" to="1462">1462</biblScope></imprint><idno type="ISSN">1862-8346</idno></series><idno type="istex">B954DF32520FA520104A6CE0C8025775F5774D2C</idno><idno type="DOI">10.1002/prca.200900023</idno><idno type="ArticleID">PRCA200900023</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1862-8346</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2‐DE</term><term>Gingivo‐buccal complex</term><term>MS</term><term>Oral cancer</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tobacco‐related oral cancer is the most common cancer among Indian males, gingivo‐buccal complex (GBC) being the most affected subsite due to the habit of chewing tobacco. Proteins from the lysates of microdissected normal and transformed epithelium from clinically well‐characterized tissue samples of the GBC were separated by two‐dimensional gel electrophoresis to identify differentially expressed proteins. Eleven protein spots showed differential expression, which could withstand the stringency of statistical evaluation. The observations were confirmed with additional tissues. Nine of these differentiators were identified by MS as lactate dehydrogenase B, α‐enolase, prohibitin, cathepsin D, apolipoprotein A‐I, tumor protein translationally controlled‐1, an SFN family protein, 14‐3‐3σ and tropomyosin. Cluster analysis indicated that these proteins, as a coexpressed set, could distinguish normal and transformed epithelium. Functionally, these differentiator molecules are relevant to the pathways and processes that have been previously implicated in oral carcinogenesis and could therefore be investigated further as a panel of markers for management of cancer of the GBC.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Inde</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Inde"><noRegion><name sortKey="Govekar, Rukmini B" sort="Govekar, Rukmini B" uniqKey="Govekar R" first="Rukmini B." last="Govekar">Rukmini B. Govekar</name></noRegion><name sortKey="Agarwal, Jaiprakash" sort="Agarwal, Jaiprakash" uniqKey="Agarwal J" first="Jaiprakash" last="Agarwal">Jaiprakash Agarwal</name><name sortKey="Alok Pathak, K" sort="Alok Pathak, K" uniqKey="Alok Pathak K" first="K." last="Alok Pathak">K. Alok Pathak</name><name sortKey="Chinoy, Roshan F" sort="Chinoy, Roshan F" uniqKey="Chinoy R" first="Roshan F." last="Chinoy">Roshan F. Chinoy</name><name sortKey="D Cruz, Anil K" sort="D Cruz, Anil K" uniqKey="D Cruz A" first="Anil K." last="D'Cruz">Anil K. D'Cruz</name><name sortKey="Dinshaw, Ketayun A" sort="Dinshaw, Ketayun A" uniqKey="Dinshaw K" first="Ketayun A." last="Dinshaw">Ketayun A. Dinshaw</name><name sortKey="Gadewal, Nikhil" sort="Gadewal, Nikhil" uniqKey="Gadewal N" first="Nikhil" last="Gadewal">Nikhil Gadewal</name><name sortKey="Kane, Shubhada V" sort="Kane, Shubhada V" uniqKey="Kane S" first="Shubhada V." last="Kane">Shubhada V. Kane</name><name sortKey="Kannan, Sadhana" sort="Kannan, Sadhana" uniqKey="Kannan S" first="Sadhana" last="Kannan">Sadhana Kannan</name><name sortKey="Malgundkar, Siddhi A" sort="Malgundkar, Siddhi A" uniqKey="Malgundkar S" first="Siddhi A." last="Malgundkar">Siddhi A. Malgundkar</name><name sortKey="Sirdeshmukh, Ravi" sort="Sirdeshmukh, Ravi" uniqKey="Sirdeshmukh R" first="Ravi" last="Sirdeshmukh">Ravi Sirdeshmukh</name><name sortKey="Sundaram, Curam S" sort="Sundaram, Curam S" uniqKey="Sundaram C" first="Curam S." last="Sundaram">Curam S. Sundaram</name><name sortKey="Zingde, Surekha M" sort="Zingde, Surekha M" uniqKey="Zingde S" first="Surekha M." last="Zingde">Surekha M. Zingde</name></country><country name="Canada"><region name="Manitoba"><name sortKey="Alok Pathak, K" sort="Alok Pathak, K" uniqKey="Alok Pathak K" first="K." last="Alok Pathak">K. Alok Pathak</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F66 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F66 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B954DF32520FA520104A6CE0C8025775F5774D2C
|texte= Proteomic profiling of cancer of the gingivo‐buccal complex: Identification of new differentially expressed markers
}}
| This area was generated with Dilib version V0.6.29. |  |